Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and
damage. RA attacks the lining of the joints (synovium), causing swelling that can result in
aching and throbbing, and eventually deformity. Even though there have been many advances in
the treatment of RA, psoriatic arthritis (PsA), and other inflammatory arthritis, doctors
still do not know what causes this inflammation in joints. It is likely that RA occurs as a
result of a complex combination of factors, including a person's genes; lifestyle choices,
such as smoking and diet; and things in a person's environment, including bacteria or
viruses. This study investigates the hypothesis that bacteria living in a person's mouth
and/or intestinal tract are responsible, at least in part, for the development of Rheumatoid
Arthritis. The investigators believe that by killing those bacteria with antibiotics, they
might be able to understand how the immune system works and, maybe, what causes RA.
Phase:
N/A
Details
Lead Sponsor:
New York University School of Medicine NYU Langone Health
Collaborators:
Memorial Sloan Kettering Cancer Center National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)