Role of Parasympathetic Activity in Mild to Moderate Asthma With Irreversible or Fixed Airflow Obstruction

• Status: Not yet recruiting
• Trial end date: 2023-06-30

Summary

In asthma, the major role of pathogenesis is chronic airway inflammation, bronchial hyperresponsiveness, and variable airflow obstruction, moreover, the autonomic nervous system also plays an important role in asthma, especially from the parasympathetic promoting bronchoconstriction and regulating airway inflammation and remodeling. Asthma with irreversible or fixed airflow obstruction (FAO) is a clinical phenotype. Although this condition frequently occurs in patients with severe asthma, there are pieces of evidence occurring in those with mild to moderate asthma. According to previous research, low lung function, FEV1 less than 60% predicted, is a strong independent predictor of subsequent asthma attacks and other asthma outcomes including asthma control and SABA use. In a recent study, the patients with mild to moderate asthma who received mild to medium dosed inhale corticosteroid plus long-acting beta-2 agonist with or without asthma control showed evidence of FAO with or without bronchodilator reversibility, therefore parasympathetic activity may be affected on FAO in those patients.

The hypothesis of this study is a cholinergic mechanism may be a major role in FAO in mild to moderate asthma severity.

• Phase: Phase 3

Details

• Lead Sponsor: Hat Yai Medical Education Center
• Treatments: Albuterol; Bromides; Ipratropium