Wheezy infants were tested for gastro-esophageal reflux disease (GERD) using combined
multiple channel intraluminal impedance-pH (MII-pH), esophagogastroduodenoscope (EGD), lipid
laden macrophage index and BAL pepsin. Wheezy infants with abnormal MII-pH or reflux
esophagitis were given domperidone and omeprazole then re-evaluated for symptoms control and
exacerbations recurrence.