Overview

Role of Perfusion CT in Pancreatic Cancer

Status:
Active, not recruiting
Trial end date:
2021-09-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is 1. to determine whether the perfusion parameters in the normal pancreas and the pancreas cancer (adenocarcinoma or neuroendocrine tumor) are different on perfusion CT 2. to determine whether initial perfusion parameters as well as perfusion parameter change in pancreas adenocarcinoma before and after chemotherapy are different between chemotherapy response group (CR, PR according to RECIST 1.1) and non response group (SD, PD according to RECIST 1.1).
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Seoul National University Hospital
Treatments:
Pancreatin
Pancrelipase
Criteria
Inclusion Criteria:

- patients who are older than eighteen years

- patients in whom operation and preoperative computed tomography are scheduled for
resectable pancreas adenocarcinoma or pancreas neuroendocrine tumor

- patients in whom chemotherapy is scheduled for histologically confirmed pancreas
adenocarcinoma

- patients in whom chemotherapy is planned for highly suspicious pancreas adenocarcinoma
on imaging workup

- patients who agree with the study and whose informed consent is obtained.

Exclusion Criteria:

- patients who are younger than eighteen years old

- patients in whom previously radiation therapy was performed and the RTx field includes
pancreas

- patients with recurred pancreas adenocarcinoma

- patient who are pregnant or nursing patients

- patients with renal failure (GFR<30mL/min)

- patients with history of malignancy, except malignancy is in complete remission after
operation or iodine therapy for at least five years)

- patients with hypersensitivity for iodine or contrast media or other causes of
contraindication of contrast-media enhanced CT scan

- Any other condition which, in the opinion of the Investigator, would make the patient
unsuitable for enrollment or could interfere with the completion of the study.