Role of Preoperative Carbohydrates Drinks, Dichloroacetate and Exercise on Postoperative Muscle Insulin Resistance

• Status: Unknown status
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to investigate whether preoperative interventions such as carbohydrate drinks, Dichloroacetate and exercise would inhibit or reverse the changes in molecular mechanisms regulating muscle carbohydrate oxidation and postoperative muscle insulin resistance in patients undergoing major abdominal surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Nottingham

Criteria

Inclusion Criteria:

• All patients over 18 years of age, who are undergoing major elective open abdominal surgery will be included in the study. Patients should be able to provide a written informed consent to participate in the study.

Exclusion Criteria:

• Patients who are

1. Undergoing emergency surgery

2. Suffering from chronic illness, (e.g. diabetes) or other debilitating diseases

3. On long term anti-inflammatory drugs, (e.g. NSAIDS, Steroids, immunosuppressant)

4. On long term antibiotics

5. On Statins

6. On full therapeutic dose of anticoagulants, or aspirin >325 mg/day, Clopidrogel >75mg/day

7. Suffering from bleeding diathesis

8. Unable to give consent

9. Pregnant or breastfeeding.