This study will focus on investigating the nicotinic acid stimulated release of prostaglandin
D2 in normal controls. In subsequent studies, the investigators would like to further explore
this pathway in people with type 2 diabetes. Enhanced blood flow (or flushing) may be
compromised or exaggerated in type 2 diabetes particularly in those with impairment of
autonomic function measured as the respiratory heart rate variability (HRV) of different
frequencies reflecting the balance between the sympathetic and parasympathetic nervous
systems. The investigators hypothesize that the vasodilatory effects induced by nicotinic
acid will be different in glabrous and hairy skin and that autonomic imbalance may alter the
response.