Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
Status:
Completed
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
This is a pilot study funded by the National Institutes of Health. In this project, we will
investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle
strength and physical function in older individuals. We propose to test a new method that may
enable simultaneous determination of both vascular and skeletal muscle NO production for the
first time in humans. Further, we will determine whether augmentation of NO-mediated
responses, by administration of sildenafil citrate (Viagra), reduces fatigue and fatigability
in older individuals.