Role of Substance P in Post-Traumatic Stress Disorder
Status:
Completed
Trial end date:
2006-01-01
Target enrollment:
Participant gender:
Summary
This study will examine the role of substance P, a chemical messenger in the brain, in
post-traumatic stress disorder (PTSD), a chronic anxiety disorder. PTSD can develop after
exposure to a terrifying event or ordeal, such as a violent personal assault, natural or
human-caused disaster, accident, or military combat. Substance P is a peptide that may be
important in the response to certain psychiatric and neurological diseases and conditions,
including anxiety.
Healthy normal volunteers and people with PTSD who are between 18 and 65 years of age may be
eligible for this study. Candidates are screened with a physical examination, blood and urine
tests, pregnancy test for women who can become pregnant, and a neuropsychological evaluation.
Participants undergo positron emission tomography (PET) and magnetic resonance imaging (MRI)
scanning. An optional lumbar puncture (spinal tap) is also requested.
PET Scanning
PET uses small amounts of a radioactive chemical called a tracer that "labels" active areas
of the brain. The tracer used in this study is [18F]SPA-RQ. For the procedure, the subject
lies still on the scanner bed. A special mask is fitted to the head to help keep the
subject's head still during the scan so the images will be clear. A 20-minute "transmission"
scan is done before the radioactive tracer is injected to provide measures of the brain that
will help in the precise calculation of information from subsequent scans. After the tracer
is injected through a needle in the arm, pictures are taken continuously for about 2 hours.
Then, 20- to 40-minute images are taken every hour until about 5 hours after the injection.
MRI Scanning
An MRI scan is scheduled at some time within 1 year of the PET scan. MRI uses a magnetic
field and radio waves to obtain images of body tissues and organs. The subject lies still on
a table inside the tunnel-like MRI scanner. Earplugs are worn to muffle loud noises that
occur during the scanning. The maximum duration of the scan is 60 minutes.
Lumbar Puncture
Lumbar puncture is used to examine the cerebrospinal fluid (CSF) that surrounds both the
brain and the spinal cord. For this procedure, a local anesthetic is given to numb the skin
in the lower back area. A small needle is then inserted into the space between the bones in
the lower back where the CSF circulates below the spinal cord. A small amount of fluid is
collected through the needle.
Blood Draw
A blood sample is collected to generate cell lines that can be used to extract DNA (genetic
material) for gene studies and that can be frozen for future use.
Details
Lead Sponsor:
National Institute of Mental Health (NIMH)
Treatments:
(2-fluoromethoxy-5-(5-trifluoromethyltetrazol-1-yl)benzyl)(2-phenylpiperidin-3-yl)amine Neurokinin A Substance P