Overview

Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity

Status:
Recruiting
Trial end date:
2025-11-30
Target enrollment:
Participant gender:
Summary
The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake. The investigators will test the hypothesis that removal of sympathetic vasoconstriction can result in improvement in insulin-mediated vasodilation and subsequently sensitivity to insulin-mediated glucose uptake.
Phase:
Phase 1
Details
Lead Sponsor:
Vanderbilt University Medical Center
Treatments:
Adrenergic alpha-Antagonists
Adrenergic Antagonists
Nitroprusside
Phentolamine