Ropivacaine Versus Ropivacaine Plus Mepivacaine for Sciatic Block
Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
In loco regional anesthesia, much more than for general anesthesia, the choice of the product
is largely left at the discretion of the practitioner. Two categories of local anesthetics
are distinguished according to their pharmacodynamic characteristics: products with a short
time of installation and a short duration period, and products with a longer delay of
installation of the sensitive and motor block, but with a long-term duration. Indeed, the
combined use of two products pharmacodynamically different seems to be of a practical
interest.
This study provides a comparison of the onset of action of 30 ml of ropivacaine 0.75% and
30ml of a mixture of ropivacaïne 0.75% associated with mepivacaïne 1.5% for the subgluteal
sciatic nerve block. This is a prospective randomized double-blind study where the main
criterion of judgment is the time of installation of a sensitive block compatible with
surgery in the sciatic territory nerve. Fifteen patients per group were calculated to detect
a 50% decrease of the onset of action in the combination group with a power of 90% and alpha
to 5%, according to a previous pilot study. The secondary endpoints are the intensity and
time of installation of the motor block, the duration of sensitive and motor block, the total
dose of morphine administered within 48 hours, as well as its possible side effects.