Rosiglitazone Versus Theophylline in Asthmatic Smokers

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Asthmatic smokers display a blunted response to both inhaled and oral corticosteroid treatments and are at increased risk for exacerbations and near fatal asthma. The prevalence of smoking in asthmatics runs between 20-30%. Therefore, new, more efficacious treatments are required.

Recent work has demonstrated a mechanism which may explain steroid resistance. A commonly used drug called theophylline can reverse this steroid resistance in laboratory studies. Another commonly used drug, rosiglitazone can reverse smoking induced lung inflammation in laboratory studies.

The investigators aim to study the effects of these drugs on smoking asthmatics' lung function and other parameters including quality of life and asthma control.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Glasgow
• Collaborators: Chest, Heart and Stroke Association Scotland; Chief Scientist Office of the Scottish Government; GlaxoSmithKline
• Treatments: Beclomethasone; Rosiglitazone; Theophylline

Criteria

Inclusion Criteria:

• Males or females between 18 and 60 years of age (inclusive).

• Clinical diagnosis of mild or moderate persistent asthma in accordance with the Global Initiative for Asthma (GINA) criteria

• Have had a history of asthma for a minimum of 6 months prior to entry into the study

• Subjects must be current cigarette smokers with a minimum five-pack-year smoking history

• Baseline FEV1 that is greater than 50% predicted; and reversibility of 12% or more at screening, washout or randomisation.

• Capable of providing signed written informed consent and complying with all the specified study procedures.

Exclusion Criteria:

• Asthma exacerbation or a respiratory tract infection within four weeks of screening.

• Type 1 or type 2 diabetes mellitus.

• Women who are lactating, pregnant, or planning to become pregnant.

• Clinically significant renal or hepatic laboratory values (e.g. AST/ALT/total bilirubin/AP > 2.5 times normal values).

• Anaemia (< 11 g/dL for males or < 10 g/dL for females)

• Contraindications to treatment as outlined in any of the product labels

• Prior history of severe oedema or serious fluid related event (e.g., heart failure) associated with any TZD

• The subject has a history of significant hypersensitivity to study drugs

• Presence of unstable or severe angina or congestive heart failure (NYHA class III/IV) or evidence or history of known congestive heart failure (NYHA class I-IV) or an abnormal electrocardiogram (ECG), as determined by the Investigator, or subjects who have had new cardiac events (such as MI, new CHF, PTCA, CABG) within 6 months of screening.

• History or suspicion of current drug abuse or alcohol abuse within the last 6 months.

• History suggestive of active infection or non-asthma lung pathology

• Clinically significant renal disease, metabolic syndrome, cirrhosis (Child-Pugh Class B/C), hypertension or any other clinically significant cardiovascular, neurological, endocrine, or haematological abnormalities that are uncontrolled on permitted therapy.

• Risk factors for human immunodeficiency virus (HIV), hepatitis B or hepatitis C infection at Screening (Visit 1)

• Subjects who are morbidly obese, defined as having a body mass index (BMI) > 40 kg/m2

• Unable to perform spirometry

• Subjects who require treatment with any of the following asthma medications from Screening (Visit 1) until study completion:

• Inhaled cromolyn sodium or nedocromil;

• Ipratropium bromide;

• Xanthines (theophylline preparations);

• Leukotriene modifiers;

• Long-acting inhaled beta2-agonists (salmeterol, formoterol);

• Oral beta2-agonists.

• Treatment with oral, intravenous or intra-articular corticosteroids within 6 weeks of Screening or thereafter.

• Subjects who have been taking in excess of 1000 μg daily of beclomethasone (or equivalent) within 6 weeks of Screening