Rosuvastatin Effect on Serial Echocardiographic Measurement of Coronary Flow Velocity Reserve
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
In ASCOT study, lipid lowering with a statin provided additional beneficial effects in
hypertensive patients with average levels of serum total cholesterol. However, the underlying
mechanism of statins to improve clinical outcomes in hypertension is unclear and the effect
of statins on coronary flow reserve (CFR) has not been examined in hypertensive patients.
Therefore, it is clinically important and timely project to measure CFR non-invasively using
echocardiography and to elucidate the mechanism of clinical benefits of statins in
hypertensive patients with cardiovascular risk. The investigators try to evaluate the effect
of rosuvastatin on CFR by measuring the change of CFR after 1 year treatment of rosuvastatin,
and to correlate CFR with LDL-cholesterol and CRP.