S-1 and Photodynamic Therapy in Cholangiocarcinoma

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

In patients with unresectable perihilar cholangiocarcinoma, photodynamic therapy with biliary stent has been known for palliation of jaundice and improving survival. But most of therapeutic effects were expected to delay bile duct obstruction rather than to decrease the tumor. Recently orally available chemotherapeutic agent, S-1 was reported as effective in patients with bile duct adenocarcinoma. The investigators' aims of study evaluate the combined effect of photodynamic therapy and S-1.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Asan Medical Center
• Treatments: Dihematoporphyrin Ether

Criteria

Inclusion Criteria:

• Histologic or cytologic diagnosis of cholangiocarcinoma

• Not eligible for curative surgery

• Eastern Cooperative Oncology Group (ECOG) performance status of 2 or better

• No serious or uncontrolled concomitant medical illness

• Adequate bone marrow function (absolute neutrophil count ≧1,500 ul, platelet count ≧75,000/ul)

• Consent this study in letter

Exclusion Criteria:

• Another neoplasia

• Porphyria

• Pregnant or breastfeeding women