S0011, Gene Therapy & Surgery Followed by Chemo & RT in Newly Diagnosed Cancer of the Mouth or Throat
Status:
Terminated
Trial end date:
2011-07-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Inserting the p53 gene into a person's cancer cells may improve the body's ability
to fight cancer. Drugs used in chemotherapy use different ways to stop tumor cells from
dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage
tumor cells. Combining chemotherapy and radiation therapy with the p53 gene may kill more
tumor cells.
PURPOSE: Phase II trial to study the effectiveness of gene therapy plus surgery followed by
cisplatin and radiation therapy in treating patients who have newly diagnosed resectable
stage III or stage IV cancer of the mouth or throat.