S0301 Cyclosporine, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as cyclosporine, daunorubicin, and cytarabine, use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.

PURPOSE: This phase II trial is studying how well giving cyclosporine together with daunorubicin and cytarabine works in treating older patients with untreated acute myeloid leukemia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Southwest Oncology Group
• Collaborator: National Cancer Institute (NCI)
• Treatments: Cyclosporine; Cyclosporins; Cytarabine; Daunorubicin; Sargramostim

Criteria

DISEASE CHARACTERISTICS:

• Morphologically confirmed acute myeloid leukemia (AML)

• Differential diagnosis of AML based on FAB classification system

• M0-M7 (No M3)

• No blastic transformation of chronic myelogenous leukemia

• Must be currently registered on protocols SWOG-9007 and SWOG-S9910

PATIENT CHARACTERISTICS:

Age

• 56 and over

Performance status

• Zubrod 0-3 (for patients 56 to 60 years of age) OR

• Zubrod 0-2 (for patients 61 to 70 years of age) OR

• Zubrod 0-1 (for patients 71 years of age and over)

Life expectancy

• Not specified

Hematopoietic

• Not specified

Hepatic

• Bilirubin no greater than 2 times upper limit of normal (ULN) unless elevated unconjugated hyperbilirubinemia is secondary to Gilbert's syndrome or hemolysis and not to liver dysfunction

• AST and/or ALT no greater than 4 times ULN

Renal

• Creatinine no greater than 1.5 times ULN AND/OR

• Creatinine clearance greater than 40 mL/min

Cardiovascular

• Left ventricular function normal

• Ejection fraction at least 50% by MUGA or echocardiogram

• No unstable cardiac arrhythmias

• No unstable angina

Other

• Not pregnant or nursing

• Fertile patients must use effective contraception

• No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated stage I or II cancer that is currently in complete remission

PRIOR CONCURRENT THERAPY:

Biologic therapy

• No concurrent pegfilgrastim

Chemotherapy

• At least 30 days since prior low-dose cytarabine (less than 100 mg/m^2/day) for myelodysplastic syndromes and recovered

• Prior hydroxyurea to control high cell counts allowed

• No prior systemic chemotherapy for acute leukemia

• Concurrent single-dose intrathecal chemotherapy allowed

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified