S0508: Thalidomide and Temozolomide in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Thalidomide may stop the growth of melanoma by blocking blood flow to the tumor.
It may also stimulate the immune system in different ways and stop tumor cells from growing.
Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth
of tumor cells, either by killing the cells or by stopping them from dividing. Giving
thalidomide together with temozolomide may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving thalidomide together with
temozolomide works in treating patients with stage IV melanoma that cannot be removed by
surgery.