S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer
Status:
Completed
Trial end date:
2019-09-19
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, fluorouracil,
irinotecan hydrochloride, and docetaxel, work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Combining more than one
drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy
is more effective in treating tumor cells.
PURPOSE: This randomized phase II trial studies how well oxaliplatin, leucovorin calcium, and
fluorouracil work compared to irinotecan hydrochloride and docetaxel in treating patients
with esophageal cancer, gastric cancer, or gastroesophageal junction cancer.