Overview

S9715, Chemotherapy and Radiation Therapy in Treating Patients With Advanced Cancer of the Nasopharynx

Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug and combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of chemotherapy plus radiation therapy in treating patients with advanced cancer of the nasopharynx.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Southwest Oncology Group
Collaborators:
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)
Treatments:
Fluorouracil
Criteria
DISEASE CHARACTERISTICS: Histologically proven nasopharyngeal carcinoma (excluding
adenocarcinoma), stage III or IV with no evidence of distant metastatic disease (M0) No
lung, bone, or liver metastases as proven within 42 days of registration by: -CT scan or
nucleotide study of the chest or chest x-ray -liver and bone scan if alkaline phosphatase
is greater than the institutional upper limit of normal (ULN), or if clinically indicated
-liver scan if SGOT is greater than the institutional ULN

PATIENT CHARACTERISTICS: Age: Any age Performance status: SWOG 0-2 Life expectancy: Not
specified Hematopoietic: Absolute granulocyte count at least 1,500/mm3 Platelet count at
least 75,000/mm3 Hepatic: Not specified Renal: Creatinine no greater than 1.6 mg/dL AND/OR
Creatinine clearance at least 50 mL/minute Other: Not pregnant or nursing Women/men of
reproductive potential must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No previous
chemotherapy to the primary site or nodes Endocrine therapy: Not specified Radiotherapy: No
previous radiotherapy (except for nonmelanomatous skin cancer outside of the radiation
therapy treatment volume) Surgery: No previous surgery to the primary site or nodes