Overview

SM-88 as Maintenance Therapy for Advanced Ewing's Sarcoma Patients and as Salvage Therapy for Sarcoma Patients

Status:
Recruiting
Trial end date:
2023-10-31
Target enrollment:
Participant gender:
Summary
The primary objective is to evaluate the efficacy of SM-88, a combination metabolic cancer treatment, in two study cohorts: - Clinically advanced Ewing's Sarcoma patients who have not progressed at the conclusion of systemic treatment - Clinically advanced sarcoma patients in the salvage treatment setting Up to 24 efficacy evaluable patients (up to 12 per cohort) will be enrolled. Study patients will receive oral SM-88, with scheduled safety and efficacy evaluations.
Phase:
Phase 2
Details
Lead Sponsor:
Sarcoma Oncology Research Center, LLC
Collaborators:
Joseph Ahmed Foundation
Tyme, Inc
Treatments:
alpha-Methyltyrosine
Everolimus
Methoxsalen
Phenytoin
Sirolimus