SPECT Investigation Of The NMDA Receptor System In Healthy Volunteers And Patients With Schizophrenia
Status:
Terminated
Trial end date:
2005-07-01
Target enrollment:
Participant gender:
Summary
This study was designed to compare the [123]I-CNS 1261 binding to NMDA receptor between
healthy volunteers and different subgroups of schizophrenic patients. Investigation of the
potential influence of antipsychotic and concomitant medication on [123I] CNS 1261 binding is
also relevant.Fifteen healthy subjects (male and female of non-child bearing potential) will
be recruited and 40 schizophrenic patients divided in 3 subgroups as indicated before:
Subgroup a) treatment-naive, (n=10); Subgroup b) on stable treatment with risperidone
(without criteria of deficit syndrome on the SDS scale, (n=15);Subgroup c) on stable
treatment with risperidone fitting criteria of deficit syndrome on the SDS scale, (n=15).