SSRI Effects on Semen Parameters in Men

• Status: Completed
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: Male

Summary

According to the National Institute of Mental Health, depressive disorders afflict over six million U.S. men annually. Most cases of moderate or severe depression are treated with antidepressants, including monoamine oxidase inhibitors, tricyclic antidepressants, and, more recently, selective serotonin reuptake inhibitors (SSRIs) and antidepressants with modest serotonin and norepinephrine reuptake inhibition but unknown mechanism-of-action. Over the past two years, prescribing data show a steady increase in antidepressant dispensing rates (especially including serotonin reuptake inhibitors) for adults. SSRIs are known to have an effect on ejaculatory function and are therapeutically used for treatment of premature (rapid) ejaculation. However, few studies have evaluated the potential impact of antidepressant medications on male fertility, and no studies have been published with respect to the impact of newer antidepressants, such as SSRIs, on male fertility. In the high-volume male infertility practice at New York Hospital-Cornell Medical Center, several patients have presented who have had a clear temporal association between SSRI use and impairment in sperm motility and/or sperm transport (emission). These men have shown improvement in sperm counts and motility after discontinuation of antidepressant medications.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Weill Medical College of Cornell University
• Treatments: Paroxetine; Serotonin; Serotonin Uptake Inhibitors

Criteria

Inclusion Criteria:

• Normal, healthy male volunteers, ages 18-65

• Must be able to swallow pills

Exclusion Criteria:

• Known sexual dysfunction

• Tobacco use

• Prescription medications

• History of psychiatric disorders

• Previous chemotherapy or radiation treatment

• History of seizure disorder

• Alcohol use greater than 2 ounces daily

• Illicit drug use

• Azoospermia on screening semen analysis

• Varicocele

• Currently attempting to achieve pregnancy