STAT Inhibitor OPB-111077, Decitabine and Venetoclax in Treating Patients With Acute Myeloid Leukemia That Is Refractory, Relapsed or Newly Diagnosed and Ineligible for Intensive Chemotherapy

• Status: Recruiting
• Trial end date: 2023-11-25
• Target enrollment: 0
• Participant gender: All

Summary

This phase I trial studies the side effects and best dose of STAT inhibitor OPB-111077 when given together with decitabine and venetoclax in treating patients with acute myeloid leukemia that does not respond to treatment (refractory), has come back (relapsed), or is newly diagnosed and ineligible for intensive chemotherapy. STAT inhibitor OPB-111077 and decitabine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as venetoclax, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving STAT inhibitor OPB-111077, decitabine, and venetoclax may work better in treating patients with acute myeloid leukemia compared to decitabine alone.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University
• Collaborator: Otsuka America Pharmaceutical
• Treatments: Azacitidine; Decitabine; Venetoclax

Criteria

Inclusion Criteria:

• Patients must have histologic evidence of high risk acute myeloid leukemia defined as one of the following:

• Non-M3 AML refractory to standard primary induction therapy

• Non-M3 AML relapsed after (i) any standard induction therapy (ii) any number of standard or experimental salvage therapies

• Newly diagnosed non-M3 AML not eligible for intensive induction chemotherapy

• Subjects must have an Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less

• Subjects must have a life expectancy of at least 4 weeks

• Subjects must be able to consume oral medication

• Subjects must have recovered from the toxic effects of any prior chemotherapy to= < grade 1 (except alopecia)

• Creatinine clearance (CrCL) >= 45

• Total bilirubin =< 2 x upper limit of normal (ULN)

• Serum glutamate pyruvate transaminase (SGPT) alanine aminotransferase (ALT) =< 2 x ULN

• Negative pregnancy test for women with child-bearing potential

• Patients must be able to sign consent and be willing and able to comply with scheduled visits, treatment plan and laboratory testing

Exclusion Criteria:

• Subjects with FAB M3 (t(15;17)(q22;q21)[PML-RARalpha]) are not eligible

• Subjects must not be receiving any chemotherapy agents (except hydroxyurea); intrathecal methotrexate and cytarabine are permissible

• Subjects must not be receiving growth factors, except for erythropoietin

• Subjects with a "currently active" second malignancy, other than non-melanoma skin cancer, carcinoma in situ of the cervix, resected incidental prostate cancer (staged pT2 with Gleason score =< 6 and postoperative prostate-specific antigen [PSA] < 0.5 ng/mL), or other adequately treated carcinoma-in-situ are ineligible; patients are not considered to have a "currently active" malignancy if they have completed therapy and are free of disease for >= 1 year

• Subjects with uncontrolled high blood pressure, unstable angina, symptomatic congestive heart failure (New York Heart Association [NYHA] class 3), myocardial infarction within the past 6 months or serious uncontrolled cardiac arrhythmia are not eligible

• Subjects with other severe concurrent disease which in the judgment of the investigator would make the patient inappropriate for entry into this study are ineligible

• Subjects must not have evidence of active leukemia in the central nervous system (CNS)

• Subjects must not have received any investigational agents within 14 days or 5 half-lives (whichever is longer) of study entry

• Subjects must not be pregnant or breastfeeding; pregnancy tests must be obtained for all females of child-bearing potential; pregnant or lactating patients are ineligible for this study; males or women of childbearing potential may not participate unless they have agreed to use an effective contraceptive method (defined as hormonal contraceptives, intrauterine devices, surgical contraceptives, or condoms)

• Subjects who have uncontrolled infection are not eligible; patients must have any active infections under control; fungal disease must be stable for at least 2 weeks before study entry

• Subjects with bacteremia must have documented negative blood cultures prior to study entry

• Subjects who are suitable for and willing to receive standard intensive induction therapy

• Subjects who are candidates for allogeneic transplantation, have a suitable donor, and are willing to undergo transplantation