Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome

• Status: Unknown status
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Probiotics are friendly bacteria normally present in food products like yogurt whereas irritable bowel syndrome is a longstanding functional disorder characterized by abdominal pain and altered bowel habits either diarrhea or constipation dominant without a definitive etiology.

Study Hypothesis:Does probiotics(Saccharomyces boulardii improves daily bowel symptoms and quality of life in patients with diarrhea dominant irritable bowel syndrome?

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aga Khan University

Criteria

Inclusion Criteria:

• Patients will be recruited from gastroenterology clinic at Aga Khan University hospital with diagnosis of diarrhea dominant irritable syndrome.

• Age between 18- 60 years.

• Male and female both.

• Organic gastrointestinal diseases excluded by baseline laboratory and sigmoidoscopy/colonoscopy and biopsy within last 2 years.

• All Patients need to satisfy ROME III criteria

Exclusion Criteria:

• Age < 18 and > 60 years

• Pregnant and lactating females

• Patients on laxatives or antidiarrheal drugs that could influence the motility of gut

• Patient on antibiotics or within 2 weeks of starting protocol.

• Not willing to participate

• Non-compliant in run in period.

• Patients taking Husk.

• Diabetic patients