Safety, Pharmacokinetics and Potential Activity of HE3286 in Obese Adult Subjects

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The objectives of this study are to evaluate the safety, tolerance and pharmacokinetics of HE3286 when administered daily for 28 days to obese adult subjects and to assess potential activity of HE3286 to decrease insulin resistance. An open-label cohort of 6 patients with type II diabetes mellitus will be treated at 10 mg (5 mg BID).

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Harbor Therapeutics
• Treatments: Dehydroepiandrosterone

Criteria

Main Inclusion Criteria:

• Males or females between 18 and 65 years of age

• Body mass index for females between 29 and 35 kg/m2 and no more than 37 kgm2 for males

• Fasting blood glucose level < 126 mg/dL at screening

• 2 hour postprandial (following 75 grams glucose) blood glucose between 140 to 200 mg/dL

• Normal thyroid stimulating hormone with or without thyroid replacement therapy

• Fasting triglycerides < 350 mg/dL

• For females of reproductive potential, agree to avoid pregnancy during the study and for 3 months following study completion, have a negative serum and/or urine pregnancy test, and use an acceptable method of birth control

• Non-smoker or has not smoked for 6 months prior to the screening visit

• No history of alcohol abuse within 2 years

• Negative drug screen at screening and baseline

• Stable weight (+/- 5%); no history of weight loss or gain (> 10% body weight)

• Must provide voluntary, written, informed consent prior to screening evaluations

• Must be able to swallow capsules

Main Exclusion Criteria:

• Marked prolongation of QT/QTc interval or history of additional risk factors for Torsades de Pointes at screening or baseline

• Positive for HIV, HAV, HBV or HCV

• History of clinically significant cardiovascular, hepatic, respiratory or renal or endocrine disorders

• History of breast and/or prostate cancer

• Clinically significant neurological or psychiatric condition, uncontrolled hypertension, clinically significant unstable medical abnormality, chronic disease or active, serious clinical infection or condition

• Personal or family member with breast and/or prostate cancer

• Malignancy within past 5 years except for successfully treated basal cell carcinoma of the skin

• Personal and/or family history of venous thromboembolism

• History of stroke and/or heart attack

• Medication prohibited from study