Safety Profile Comparison of Undiluted Intracameral Moxifloxacin vs. Levofloxacin in Cataract Surgery

• Status: Recruiting
• Trial end date: 2023-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this randomized clinical trial study is to compare safety profile undiluted intracameral moxifloxacin vs levofloxacin during cataract surgery. The main question it aims to answer is whether moxifloxacin and levofloxacin have similar safety profile.

Participant will be randomized into two treatment arms. All participant will receive standardized treatment before, during, and after surgery and will be followed up at one day, one week, and one month after surgery.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Melva Louisa
• Treatments: Levofloxacin; Moxifloxacin; Ofloxacin; Ophthalmic Solutions

Criteria

Inclusion Criteria:

• Imature senile cataract in one or both eye

• Agree to be included and signed informed consent

Exclusion Criteria:

• Have a history of allergy to moxifloxacin or levofloxacin or any other antibiotics

• Other ocular comorbids such as uveitis, glaucoma, diabetic retinopathy, pseudoexfoliation, and endothelial disorders

• Ocular surgery prior to study

• Sign of infection or inflammation around the eye

• Cataract density more than grade 4 according to LOCS III grading

• Corneal endothelial cell density < 1500 cell/ mm2

• Anterior chamber depth < 2.5 mm

• Diabetes mellitus type 2