Safety Study of 2DG With Stereotactic Radiosurgery
Status:
Withdrawn
Trial end date:
2008-06-01
Target enrollment:
Participant gender:
Summary
Ionizing radiation produces cancer cell death by creating high levels of reactive oxygen
species (ROS), such as superoxide and hydrogen peroxide, in irradiated cells. Cancer cells
are preferentially affected by ROS. The investigators, therefore, propose that interfering
with the detoxification of ROS will make radiation more toxic to cancer cells. Several
cellular mechanisms exist to detoxify ROS, and glucose metabolism plays an important role in
many of these mechanisms. The investigators propose that interfering with glucose metabolism
will sensitize cancer cells to radiation.
The investigators' central hypothesis is that 2DG will sensitize cancer cells to ionizing
radiation by inhibiting the use of glucose to detoxify reactive oxygen species produced by
radiation. As an initial step to evaluate this hypothesis, the investigators have designed
this phase I study.