Safety Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Tumors of the Brain
Status:
Terminated
Trial end date:
2019-02-28
Target enrollment:
Participant gender:
Summary
The prodrug, 5-Aminolevulinic acid (ALA), has been shown to lead to intracellular
accumulation of fluorescent porphyrins in high grade malignant gliomas in the brain. On
imaging, this accumulation of fluorescent porphyrins helps delineate tumor borders, resulting
in the surgeon being better able to visualize and thus able to make a complete, or
near-complete resection of the tumor.