Safety Study of Cell Therapy to Treat Chronic Obstructive Pulmonary Disease

• Status: Completed
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the cell therapy with bone marrow mononuclear cells is safe in the treatment of chronic obstructive pulmonary disease, specifically the pulmonary emphysema.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: UPECLIN HC FM Botucatu Unesp
• Collaborators: Instituto de Molestias Cardiovasculares; Laboratório de Genética Humana e Terapia Celular, Unesp - Assis

Criteria

Inclusion Criteria:

• diagnosis of severe chronic obstructive pulmonary disease

• ineffective clinical treatment

• limited life expectancy

• limitations in daily physical activity

• possibility of pulmonary rehabilitation physiotherapy

• acceptable nutritional status

• acceptable cardiac function

• at least six months smoking cessation

• family support

• modified medical research council dyspnea scale stage > 3

Exclusion Criteria:

• pulmonary or extra-pulmonary infection

• severe coronary disease and/or ventricular dysfunction

• significant kidney or liver disease

• immunosuppressive disease

• active smoker

• cancer

• psychosocial problems

• established medical protocol

• family rejection

• pregnancy