Safety Study of Cervical Sympathetic Block for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage

• Status: Terminated
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the feasibility of performing a cervical sympathetic block in patients with severe cerebral vasospasm involving the anterior cerebral circulation following aneurysmal SAH.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Washington
• Treatments: Bupivacaine; Clonidine

Criteria

Inclusion Criteria:

1. High grade spontaneous SAH (Fisher Grade III and IV)

2. Secured aneurysm (clipped/coiled)

3. Evidence of severe vasospasm - MCA mean flow velocity >200 cm/sec and Lindegaard ratio >6 OR Symptomatic vasospasm with either angiographic evidence (no angioplasty), or at least moderate severity according to TCD criteria (MCA mean flow velocity >150 cm/sec and Lindegaard ratio >3, or ACA vasospasm)

4. Age ≥18

Exclusion Criteria:

1. Allergy to local anesthetic or contrast

2. Coagulation disorders with PT <70%, or INR >1.4, or PTT >1.5 times control and/or platelets <70,000x106/L

3. Use of enoxaparin within 12 hours

4. Use of clopidogrel within 7 days

5. Use of coumadin within 5 days

6. Use of ticlopidine within 14 days

7. Use of intravenous thrombolytics within 10 days

8. Any use of hirudin derivatives during ICU stay