Safety Study of Intravenous Hydromorphone Using Incremental 1mg Doses up to 2mg for Adult ED Patients
Status:
Completed
Trial end date:
2007-11-01
Target enrollment:
Participant gender:
Summary
We wish to examine the safety and speed of onset of giving a dose of 1mg hydromorphone
followed by an additional 1mg. Eligible patients will be given 1 mg intravenous (IV)
hydromorphone. At 15 minutes, these patients will be asked the question, "Do you need more
pain medication?" Those that answer "yes" will receive an additional 1mg IV hydromorphone.
Those that answer "no" will not receive additional pain medications at that time period (15
minutes). Thus, we wish to give up to 2 mg IV hydromorphone titrated to patients' pain, which
we believe will result in less incidence of oxygen desaturation.
If our study shows that this regimen is safe, its efficacy can be assessed in future trials.
Positive results of those trials may lead to the use of this regimen to improve pain
management in the emergency department.