Safety Study of MKC-1 Combined With Pemetrexed to Treat Advanced Cancer and Non-Small Cell Lung Cancer
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
To determine the toxicities, maximum tolerated dose (MTD) and recommended phase 2 dose of
MKC-1 when administered orally, twice daily for 14 days followed by 7 days without dosing, in
combination with pemetrexed (delivered at its recommended single agent dose) to patients with
advanced solid tumor malignancies. Also, to determine the antitumor activity, based on the
objective response rate and median Progression Free Survival ("PFS"), of oral MKC-1,
administered on this schedule in combination with pemetrexed to patients with non small cell
lung cancer (NSCLC).