Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm
Status:
Withdrawn
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
Rupture of a cerebral aneurysm is a serious medical condition that may result in permanent
disability or even death just related to the aneurysm rupture itself. Patients who undergo
successful surgical treatment of their aneurysm will rarely experience problems related to
that specific aneurysm in the future. However, blood that is on the surface of the brain from
the initial aneurysm rupture is very irritating to other blood vessels that it comes in
contact with. When these blood vessels become irritated, they spasm and become narrower. This
narrowing restricts blood flow through the vessel, and if severe can result in a stroke that
is caused by inadequate blood flow through the vessel. Depending on location and severity,
this condition of vessel spasm (cerebral vasospasm) may result in permanent disability or
death. Treatment to prevent cerebral vasospasm decreases the risk of stroke. This research is
trying to see if a medication that is FDA approved for the treatment of lung disease and
sexual dysfunction can be used to prevent and/or treat cerebral vasospasm.