Safety Study of Using Stem Cells to Stimulate Development of New Blood Vessels in Peripheral Vascular Disease

• Status: Unknown status
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if bone marrow derived adult stem cells are safe and effective in inducing development of new blood vessels (angiogenesis) in the legs of patients with severe peripheral vascular disease.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Murphy, Michael P., MD
• Collaborator: Indiana University School of Medicine

Criteria

Inclusion Criteria:

• Severe peripheral vascular disease not amenable to bypass or angioplasty

• Age >21 years old

• Normal renal function (creatinine < 1.6)

Exclusion Criteria:

• Congestive heart failure (ejection fraction [EF]<30%)

• History of cancer or myeloproliferative disorders

• Proliferative retinopathy

• Pregnancy

• Cognitively disabled