Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The study is being done to see if a drug shown to lower the risk of heart failure is also effective in reducing the stiffness of the arteries.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Chicago
• Collaborator: Forest Laboratories
• Treatments: Metoprolol; Nebivolol

Criteria

Inclusion Criteria:

• Established Type 2 diabetic not treated with insulin

• Stage 1 hypertensives blood pressure > 130/80 mmHg and < 160/100 mmHg

• BMI < 35

• Hemoglobin A1C < 8.5

• Must be postmenopausal or taking some form of birth control of surgically sterile

Exclusion Criteria:

• Acute myocardial infarction, unstable angina, stroke or TIA within the past year.

• Active angina in the last three months

• Diabetes requiring treatment with insulin

• Severe asthma

• Female who are pregnant, planning to be pregnant during the study period, lactating or women of childbearing potential who are not using a medically approved method of contraception

• Recent history of substance or alcohol abuse .

• Uncontrolled hypertension systolic blood pressure >160mmHg or diastolic blood pressure > 100 mmHg