Safety, Tolerance, Pharmacokinetic and Antiviral Study of Amdoxovir in Combination With Zidovudine in Adults With HIV
Status:
Completed
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the short term safety, tolerance, and antiviral
effect of zidovudine (AZT) and amdoxovir (AMDX, DAPD) in combination, and whether the dosage
for AZT can be reduced, potentially decreasing side effects, while maintaining antiviral
effects.
Study hypothesis: DADP in combination with AZT is safe and effective, and AZT dosing may be
reduced, resulting in lower levels of AZT-monophosphate associated with toxicity and
maintaining levels of AZT-triphosphate associated with efficacy.