Overview

Safety and Effectiveness of Artemisinin-based Combination Therapies (ACTs) With Repeated Treatments for Uncomplicated Falciparum Malaria Over a Three-year Period

Status:
Unknown status

Trial end date:
2013-09-01

Target enrollment:

Participant gender:

Summary

A community-based, open-label, cluster-randomised longitudinal study in which children are randomized according to village health worker catchment areas comparing the safety and effectiveness of repeated treatments with artemether-lumefantrine (AL) over a 3-year period in children 4-48 months to that of repeated treatment with dihydroartemisinin-piperaquine (DHA-PPQ).

Phase:

Phase 4

Details

Lead Sponsor:

Liverpool School of Tropical Medicine

Collaborators:

Malawi-Liverpool-Wellcome Trust Clinical Research Programme
National Malaria Control Programme, Malawi
Research for Equity and Community Health Trust

Treatments:

Artemether
Artemether-lumefantrine combination
Artemether, Lumefantrine Drug Combination
Artemisinins
Dihydroartemisinin
Lumefantrine
Piperaquine