Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS)

• Status: Terminated
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Pain remains the most debilitating symptom for adult patients suffering from complex regional pain syndrome (CRPS). Most CRPS patients gain little to no relief from current painkillers. The purpose of this study is to evaluate the efficacy and safety of ethosuximide in search of much-needed adjunctive therapy to relieve the pain and suffering associated with CRPS.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: McGill University Health Center; McGill University Health Centre/Research Institute of the McGill University Health Centre
• Collaborator: McGill University
• Treatments: Ethosuximide

Criteria

Inclusion Criteria:

• Male or female, age ≥18 years old;

• Diagnosis of Complex Regional Pain Syndrome (CRPS) using International Association for the Study of Pain criteria >6 months;

• Normal liver function (AST level <3x normal level);

• Normal kidney function (serum creatinine <133µmol/L);

• Full blood count, haematocrit >38%;

• Willing and able to give informed consent and of completing study questionnaires;

• Stable (no change in past two months) but suboptimal pain pharmacotherapy (i.e. additional pain control felt by patient and physician to be necessary);

• Able to attend research centre according to the visit schedule;

• Women of child-bearing potential must be using a reliable form of contraception i.e. oral contraceptives, a barrier method (condom or diaphragm), intra-uterine device or abstinence.

Exclusion Criteria:

• Optimal response to opioids, antidepressants, anticonvulsants or anti- inflammatory medications;

• Any history or indication of kidney or liver disease;

• Any history of alcohol abuse;

• Presence of diabetes;

• Subjects taking other anti-epileptic drugs, including gabapentin, pregabalin, topiramate, phenytoin, carbamazepine, and oxcarbazepine;

• Pregnancy (a serum bHCG pregnancy test will be performed as part of the initial blood panel);

• Known or suspected allergy to succinimides, ethosuximide, methsuximide (Celontin®), phensuximide;

• Any history of mental illness or disorder, which in the investigators opinion, interferes with the subjects ability to accurately report treatment response;

• Participation in other clinical trial in the 30 days prior to enrolment.