Safety and Efficacy of CC-486 in Previously Treated Patients With Locally Advanced or Metastatic Nasopharyngeal Carcinoma
Status:
Completed
Trial end date:
2017-04-20
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the safety and efficacy of CC-486 in previously
treated patients with locally advanced or metastatic nasopharyngeal carcinoma having failed
one to two previous regimens, including platinum-based chemotherapy. Participants will be
enrolled according to a Simon two-stage design; if the predefined activity is met (>4
responses [complete response; partial response {CR/PR}] out of the first 17 evaluable
participants based on independent radiological assessment), then the study will continue to
enroll an additional 34 participants. If 4 or less responses out of 17 are observed, then the
study enrollment will be stopped.