Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy
Status:
Terminated
Trial end date:
2018-03-27
Target enrollment:
Participant gender:
Summary
Clopidogrel has been shown to slow down tumor progression in orthoptic pancreatic murine
tumor.
In a pilot study, the rate of microparticles was correlated with response rate of pancreatic
adenocarcinoma.
The aim of the study is;
- to compare the phenotypes of coagulation, the tumor progression and metastasis formation
with and without clopidogrel treatment in association with chemotherapy in advanced
pancreatic cancer patients
- to correlate the decrease of microparticles levels after one month of chemotherapy with
tumor response (ancillary study)