Safety and Efficacy of Dexmedetomidine in Painless Colonoscopy

• Status: Unknown status
• Trial end date: 2019-12-30
• Target enrollment: 0
• Participant gender: All

Summary

50 patients who undergo painless colonoscopy from May 1, 2019 to December 30, 2019 will be randomized to two groups: Propofol group: propofol is used as a sedative strategy; Dexmedetomidine group: Dexmedetomidine as a sedative strategy. Compared of comfort and pain score of patients, the occurrence of adverse events and the satisfaction score of endoscopists between two groups. This study aims to investigate whether dexmedetomidine is effectively and safely in Painless Colonoscopy, and improve the comfortable and safety of Painless Colonoscopy.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: West China Hospital
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

Patients aged 18 years who underwent painless colonoscopy； ASA I - III level； Patient informed consent；

Exclusion Criteria:

Age < 18 years; Allergic to the medicine used; Poor control of hypertension; Patients with hypovolemic or hypotension (systolic blood pressure < 80mmHg, or mean arterial pressure < 50mmHg); Severe sinus bradycardia (HR < 50 times/min) or atrioventricular block; Severe limited left ventricular function (EF<30%); Impaired renal function (GFR< 15ml/min) or requiring dialysis; Impaired liver function or drug abuse;

Withdrawal criteria:

patients require to withdraw