Safety and Efficacy of Different Combinations of Zonisamide-CR Plus Bupropion-SR to Treat Uncomplicated Obesity
Status:
Completed
Trial end date:
2007-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine which of seven combinations of Zonisamide CR and
Bupropion SR gives the best weight loss and is safe and well tolerated for the treatment of
obesity not associated with the complications of obesity such as diabetes. In a previous
study, the combination of zonisamide and bupropion SR was shown to be effective for weight
loss compared to either zonisamide, bupropion SR alone or placebo. It is thought that by
adjusting the doses of each drug, giving zonisamide in a controlled release (CR) form and
increasing the doses more slowly, more weight loss and less side effects can be attained.