Safety and Efficacy of L-NAME and Midodrine to Increase MAP

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects blood pressure and blood flow to the brain. We are going to study blood pressure while the person is seated in a wheelchair before and after we give the subject medications which should increase blood pressure in a laboratory setting and over the course of a normal day in persons with spinal cord injury.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Midodrine; NG-Nitroarginine Methyl Ester

Criteria

Inclusion Criteria:

Spinal Cord Injured Subjects:

• chronic spinal cord injury (1 year post injury) with a seated MAP of 65mmHg (almost all individuals with tetraplegia demonstrate this)

• Male or female with an age of 18 - 65 years

Control Subjects:

• Male or female with an age of 18 - 65 years

Exclusion Criteria:

Spinal Cord Injured Subjects:

• acute illness

• cardiovascular disease

• renal disease

• medications that affect the cardiovascular system

Control Subjects:

• acute illness

• cardiovascular disease

• renal disease

• medications that affect the cardiovascular system