Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Ascites in liver cirrhosis is explained by increased production of vasoactive substances
leading to renal vasoconstriction and salt and water retention. The retained water then
accumulates in the peritoneal cavity under the effect of portal hypertension and low albumin.
Refractory ascites is defined as ascites that cannot be mobilized or prevented from early
recurrence after large-volume paracentesis despite medical therapy and dietary sodium
restriction. Midodrine is an α1 receptor agonist that can improve systemic and renal
hemodynamics in non-azotemic cirrhotic patients by counteracting mesenteric vasodilatation,
which is accentuated in cirrhosis.