Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aims of this study are to assess efficacy and safety of patient-controlled analgesia (PCA) when applied to the Emergency Department setting and to compare the efficacy and safety of two PCA dosing regimens.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Albert Einstein College of Medicine; Albert Einstein College of Medicine of Yeshiva University
• Collaborators: Jacobi Medical Center; National Institute of Nursing Research (NINR); National Institutes of Health (NIH)
• Treatments: Morphine

Criteria

Inclusion Criteria:

• Patients presenting to the ED with a chief complaint of abdominal pain of less than or equal to 7 days duration

• Age 18 to 65 years

• Patient deemed by the ED attending physician to require IV opioid analgesia

Exclusion Criteria:

• Current use of prescription or non-prescription opioids

• Long-term use of opioids, chronic pain syndrome

• Clinician suspicion of opioid dependence/abuse

• Clinical suspicion of intoxication

• Pregnancy or breast-feeding

• History of chronic obstructive pulmonary disease, history of sleep apnea, oxygen saturation < 97%

• Systolic blood pressure < 100 mm Hg

• Use of monoamine oxidase inhibitors, phenothiazines, or tricyclic antidepressants

• History of renal insufficiency/renal failure

• Prior allergic reaction to morphine

• Inability to provide informed consent

• Previous entry of patient into study