Safety and Efficacy of Propionate for Reduction of LDL Cholesterol

• Status: Recruiting
• Trial end date: 2020-11-30
• Target enrollment: 124
• Participant gender: All

Summary

The objective of the trial is to evaluate a potential impact of food supplements with the short chain fatty acid propionate on blood LDL cholesterol level.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Charite University, Berlin, Germany
• Treatments: Atorvastatin Calcium; Calcium, Dietary

Criteria

Inclusion Criteria:

• patients with hypercholestrolemia and a LDL serum level of > 115 mg/dl

• age of patient between 20 and 70 years

• participant is fully competent and has given his/her written informed consent to the scheduled trial conduct

Exclusion Criteria:

• patients with acute coronary syndrome in the last 4 weeks

• patients with chronic symptomatic heart failure (NYHA 2-4)

• patients with chronic renal failure and a GFR < 45 ml/min

• patients with chronic liver disease

• patients with hematological diseases

• patients with severe diseases of other organ systems (tumors, infections)

• pregnancy