Safety and Efficacy of Unrelated Cord Blood Transplantation for Adult Patients With Hematologic Malignancies

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary purpose of this study is to evaluate the safety and efficacy of cord blood transplantation for adult patients with hematologic malignancies including refractory acute leukemia. The transplant procedure was determined in detail according to the previously published report showing a high survival, so that the investigators could expect a similar result.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Keio University
• Treatments: Cyclophosphamide; Cytarabine

Criteria

Inclusion Criteria:

• Clinical diagnosis of acute leukemia, chronic myelogenous leukemia, and myelodysplastic syndrome

• Lack of HLA-identical or 1 locus mismatched related donor

• Age over 20, and under 55

• Performance status 0 or 1

• No moderate or sever organ dysfunction (liver, kidney, heart, lungs)

• No anti-HLA antibody

• Informed consent was obtained

Exclusion Criteria:

• Uncontrollable diabetes

• Uncontrollable hypertension

• Active infection

• TPHA, HBs-Ag, HCV-Ab positive

• HTLV-I, HIV positive