Safety and Efficacy of Vaginal Microbiota Transplant (VMT) in Women With Bacterial Vaginosis (BV)
Status:
Withdrawn
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
The composition of a woman's vaginal microbiota has a significant impact on her reproductive
tract health and general quality of life. Approximately one-third of all women currently have
bacterial vaginosis (BV), a polymicrobial condition in which the vaginal microbiota is not
dominated by Lactobacillus species, leading to increased risk of various reproductive tract
maladies and negative impact on well-being. It has been suggested by epidemiological studies
that vaginal microbiota are readily transferable from one woman to another. Here,
investigators aim to explore the hypothesis that vaginal microbiota can be engrafted from one
woman to another in a controlled clinical setting by using cervicovaginal secretions (CVS), a
process referred to as vaginal microbiota transplant (VMT).