Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)
Status:
Not yet recruiting
Trial end date:
2024-04-30
Target enrollment:
Participant gender:
Summary
Infantile optic pathway glioma (OPG) is generally benign and slow-growing, but due to
infiltration and compression of sensitive neuronal structures in the optical pathways,
progressive visual loss is a frequent and highly debilitating complication of the condition.
Recently, therapeutic strategies aimed at neuroprotection in the visual pathway rather than
reducing the size of the tumor have been studied.
Nerve growth factor (NGF) (Levi-Montalcini, 1987; Levi-Montalcini et al., 1996) is a
neurotrophin that acts on peripheral and central neurons by binding with high affinity to the
trkANGFR receptor, which has tyrosine kinase activity, and with low affinity to the
non-selective pan-neurotrophin receptor p75NTR that regulates signaling through trkANGFR. The
effect of NGF on target cells depends on the ratio of these two co-distributed receptors on
the cell surface (Huang, 2003).
Recently, two studies have shown that murine NGF can prevent progression of visual damage in
OPG patients (Chiaretti et al., 2011; Falsini, 2011; Falsini, 2016). These successful
exploratory studies (the last of which was a randomized, double-blind, placebo-controlled
study) represent a significant reference point in the field of vision loss in OPG patients
and provide the basis and rationale for this study using a recombinant form of mutated NGF,
painless NGF (CHF6467), which is anticipated to prove devoid of adverse effects related to
pain at therapeutic doses.
The purpose of this randomised study is to assess the safety and efficacy of multiple doses
of painless NGF CHF6467 eye drops on the visual function of children or young adults with
optic pathway gliomas, whether or not associated with type 1 neurofibromatosis. This study
will include serial assessments of both optical pathway functionality and morphology, using
electrophysiological and magnetic resonance imaging (MRI) techniques of the brain. The
comparator will be a placebo preparation based on a physiologically balanced salt solution.
This comparator has no effect on retinal function and optic nerve, is painless and perfectly
tolerated, as reported by numerous clinical studies including that of our group (Falsini et
al., 2016).