Safety and Efficiency Study of Loading Dose Atorvastatin in Cardiac Surgery

• Status: Completed
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Statins were reported to have pleiotropic effects including antiinflammatory, anti-oxidative stress effects and stabilise plaque in some conditions. Some researches indicate loading dose statin can reduce contrast induced nephropathy, and the levels of inflammatory markers were significantly decreased. The investigators hypothesis loading dose atorvastatin may attenuate inflammatory response during cardiopulmonary bypass (CPB) and therefore reduce postoperative acute kidney injury in cardiac surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College
• Collaborator: Chinese Academy of Medical Sciences, Fuwai Hospital
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• age > 18 years old

• elective coronary artery bypass surgery in CPB

Exclusion Criteria:

• emergent surgery

• re-operation

• acute kidney dysfunction

• chronic kidney disease

• GFR < 60ml/min

• liver dysfunction

• existing myopathy

• LEVF < 40%

• statin allergic or contradictive

• pregnancy

• breast feed period