Safety and Pharmacokinetic Evaluation of Nitrite for Prevention of Cerebral Vasospasm

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to examine the safety of a 14 day infusion of sodium nitrite, and to study the pharmacokinetics of nitrite, during a 14 day infusion in patients with ruptured cerebral aneurysms.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hope Pharmaceuticals
• Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)

Criteria

Inclusion Criteria:

• Ruptured cerebral aneurysm

Exclusion Criteria:

• Pregnancy, sickle cell disease, G6PD deficiency, anticoagulant therapy